Data set: 2,2-Difluoroethanol (00.01.005)
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Type Product flow |
Name 2,2-Difluoroethanol |
Reference Flow Property Mass (kg) |
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Classification Materials production / Organic chemicals |
Synonyms Ethyl difluoroacetate; 2-Fluoroethanol; Fluoroacetate; Fluorocitrate |
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General comment 2,2-Difluoroethanol is used as a chemical intermediate. It has wide applications in medicine and fluoropolymers. Synthesis of 2,2-Difluoroethanol is from Ethyl difluoroacetate. 2-Fluoroethanol is converted by alcohol dehydrogenase (ADH) using nicotinamide adenine dinucleotide (NAD+) as cofactor, ultimately leading to the formation of fluoroacetaldehyde and then fluoroacetate. Fluoroacetate is a precursor to fluorocitrate, an inhibitor of aconitase, an enzyme that participates in the TCA cycle. |